Due to the presence of calcium carbonate which act as an antacid, a time-interval of 2 hours should be considered between the medicinal product intake and the administration of other medicinal products, especially H2-antihistaminics, tetracyclines, digoxine, fluoroquinolone, iron salt, ketoconazole, neuroleptics, thyroxine, penicillamine, beta-blockers (atenolol, metoprolol, propranolol), glucocorticoid, chloroquine, and diphosphonates.
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